Why steriods gains diminish after 8 weeks.
The following may be the answer (tentatively). this report on myostatin (a powerful muscle growth inhibitor) shows that after 8 weeks on Testoterone, myostatin levels rise significantly. Fortunately it's dependent on Testosterone levels and not muscle mass. When you stop the Test, myostatin levels go back to normal....

8-10 weeks is when the gains from a cycle peeter out.

Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.

Lakshman KM, Bhasin S, Corcoran C, Collins-Racie LA, Tchistiakova L, Forlow SB, St Ledger K, Burczynski ME, Dorner AJ, Lavallie ER.
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States.
Methodological problems, including binding of myostatin to plasma proteins and cross-reactivity of assay reagents with other proteins, have confounded myostatin measurements. Here we describe development of an accurate assay for measuring myostatin concentrations in humans. Monoclonal antibodies that bind to distinct regions of myostatin served as capture and detector antibodies in a sandwich ELISA that used acid treatment to dissociate myostatin from binding proteins. Serum from myostatin-deficient Belgian Blue cattle was used as matrix and recombinant human myostatin as standard. The quantitative range was 0.15-37.50 ng/mL. Intra- and inter-assay CVs in low, mid, and high range were 4.1%, 4.7%, and 7.2%, and 3.9%, 1.6%, and 5.2%, respectively. Myostatin protein was undetectable in sera of Belgian Blue cattle and myostatin knockout mice. Recovery in spiked sera approximated 100%. ActRIIB-Fc or anti-myostatin antibody MYO-029 had no effect on myostatin measurements when assayed at pH 2.5. Myostatin levels were higher in young than older men (mean+/-S.E.M. 8.0+/-0.3 ng/mL vs. 7.0+/-0.4 ng/mL, P=0.03). In men treated with graded doses of testosterone, myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men. Myostatin levels were not significantly associated with lean body mass in either young or older men. CONCLUSION: Myostatin ELISA has the characteristics of a valid assay: nearly 100% recovery, excellent precision, accuracy, and sufficient sensitivity to enable measurement of myostatin concentrations in men and women.
PMID: 19356623 [PubMed - in process]

Max wrote:Now that is very intersting mate! myostat inhibs are going to be HUGE

cleaver wrote:

Max wrote:Now that is very intersting mate! myostat inhibs are going to be HUGE

Probably are already if you move in the right circles and have the dosh.

kp1512 wrote:

cleaver wrote:

Max wrote:Now that is very intersting mate! myostat inhibs are going to be HUGE

Probably are already if you move in the right circles and have the dosh.

Yep - its still around $4000 though and according to Prof Lee they still havent confirmed if key organs grow. But some idiot will no doubt try them.

Another 3-4 years and this bad boy will be tested and well - we will see physqiues not even the Marvel comics thought of. I think the biggest change may be extremely slim waists and just crazy upper and lower bodies.