Reducing saturated fat intake increases LDL receptors

by **Dtlv74** on Sat Jan 09, 2010 12:55 pm

RoB wrote:Surely the pro-inflammatory effects of the PUFA's in the safflower oil will outweigh the effects of the "increased" anti-inflammatory potential of the HDL? I certainly wouldn't ever choose to consume polyunsaturates, especially omega 6's, over saturated.

Taken from the full paper, "Subjects consumed 1 of 2 isocaloric meals comprising a slice of carrot cake and a milkshake containing 1 g of fat/kg of body weight." A carrot cake or milkshake laced with extra fat hardly reflects a meal someone following a low carb diet would consume.

Sorry Rob, read your post above the other night and was too tired to get my head around it!

Yes I see where you are coming from. Have dug out and looked at the full study and there's no way of knowing for sure whether the improved functioning of the anti-inflammatory potential of the HDL was offset by the pro-inflammatory characteristic of the linoleic acid overall, but if judging the overall inflammatory potential just by the inflammatory indicator ICAM-1 (where they focused their testing) it appears that saturated fat was still more likely to cause inflammation than the polyunsaturates.

They should really have also used a third meal of monounsaturates to compare though, and I take your point.

by **RoB** on Fri Jan 15, 2010 11:45 pm

Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease1,2,3,4,5
Patty W Siri-Tarino, Qi Sun, Frank B Hu and Ronald M Krauss

ABSTRACT

Background: A reduction in dietary saturated fat has generally been thought to improve cardiovascular health.

Objective: The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.

Design: Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.

Results: During 5–23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results.

Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.

Received for publication March 6, 2009. Accepted for publication November 25, 2009.

Shame the full paper isn't published yet, but I wonder if this will start trickling down into the main stream media. Some how, I doubt it.

by **cleaver** on Sat Jan 16, 2010 12:14 am

^^ You can sure it wont unless there is a change of heart in the 'establishment'

by **Dtlv74** on Sat Jan 16, 2010 1:44 pm

It wont. The 'low fat' is automatically healthy thing seen everywhere really annoys me but looks here to stay.

From my understanding by far the biggest correlation between anythign in diet and heart/CV disease is simply continued excessive calories of any kind - macros and their individual and combined effects only become particularly relevant once the body is already on it's way to being (or already is) fucked, and it becomes about reducing the individual risk factors (excessive bodyweight, insulin resistance, LDL/HDL ratio, inflammation, arteriosclerosis, triglyceride levels etc).

The best way to be preventative by far is simply not to over eat and to match incoming energy to activity. Not smoking is the next most important thing.

by **Alex** on Sat Jan 16, 2010 2:12 pm

To be honest I think it's a more sensible approach to be telling the public that saturated fat is a bad thing. You've got to remember who you're dealing with. I'd imagine that specifying saturates that are good at this stage would be ignored and taken that all fats are ok to eat.

Remember when Atkins first became popular and everyone had fry up's all the time? I think it would be a similar situation here unfortunately. The public needs a better grasp and understanding of the basics first before going into the finer details.

Reducing saturated fat intake increases LDL receptors

Re: Reducing saturated fat intake increases LDL receptors

Re: Reducing saturated fat intake increases LDL receptors

Re: Reducing saturated fat intake increases LDL receptors

Re: Reducing saturated fat intake increases LDL receptors

Re: Reducing saturated fat intake increases LDL receptors

Who is online