Possible 75% cancer mortality reduction with Vitamin D

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Re: Possible 75% cancer mortality reduction with Vitamin D

Postby Resurrected on Sun Jan 17, 2010 5:00 pm

Just found the below post on another forum whilst browsing some Vit D info. I thought some people may be interested. So I've cut and paste it rather thatm repeat it all

http://www.grassrootshealth.net/d-action

It is a full 5 year trial. Participation includes 2 25(OH)D tests each year so I will be able to keep my status at the 60~70ng/ml 150~175nmol/l required for optimum disease prevention.
The cost of this trial is $30 every 6 months and that's roughly £20ish.

It only takes a minute to sign up and the test kit should arrive in a week or so. The cheapest UK private option I'm aware of is The Doctors Laboratory They will do a test for £40, admittedly is a Diasorin test which is the best but this ZRT test comes well recommended by Dr Cannell of the Vitamin D council and there are a lot of big Vitamin D names on the Grassroots panel so if they can't get it right then we're in serious trouble. You also have to go to your doctors for the Doctors Laboratory test, these ZRT TESTS a just a home !!!!! your finger, drop blood on test strip then return in post. Bear in mind they normally sell for $ 75.00.
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Re: Possible 75% cancer mortality reduction with Vitamin D

Postby RoB on Sun Jan 17, 2010 9:41 pm

I'm not exactly an expert on the biochemistry of it all, although i probably should be considering I'm a biochemist undergrad. But it seems pointless to me, to measure the 25-D and not the 1,25-dihydroxyvitamin-D considering the fact that 1,25-dihydroxyvitamin-D is the active metabolite, and the only form of vitamin D to transcriptionally activate the vitamin D receptor.
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Re: Possible 75% cancer mortality reduction with Vitamin D

Postby Bison on Sun Jan 24, 2010 10:23 pm

Been catching up on some supplements and research and everyone seems to have gone Vitamin D mad lol!

http://bacteriality.com/2007/09/15/vitamind/"

1.Vitamin D is not a vitamin; it is an immunosuppressive steroid.
2.The vast majority of studies fail to account for the long-term effects of vitamin D.
3. Chronically ill people are not deficient in vitamin D.
4. Healthy people are not deficient in vitamin D and do not need to consume extra amounts of this steroid.
5.The public does not require extra sun exposure in order to prevent vitamin D “deficiency.”
6.Vitamin D does not reverse osteoporosis.
7.Extra vitamin D does not reduce the risk of cancer.
8.Vitamin D deficiency does not cause rickets.
9.Most researchers fail to consider the alternate hypothesis about vitamin D.
10.When it comes to vitamin D, the current medical climate of consensus is hostile to new ideas.
11.Research touting vitamin D’s benefits is often biased, methodologically weak, and ultimately misleading. 12.The dairy and supplement industries are intent on heavily promoting vitamin D.
13.The media is neither well-informed nor objective about vitamin D.
14.We must take immediate action to remedy the health crisis that has resulted from faulty conclusions about vitamin D in chronic disease.
If you think about it, it seems little wonder that vitamin D has become so popular. It’s basically an over-the-counter steroid.

At the moment there is a significant gap in communication between the molecular biologists who have realized that “vitamin D” is a steroid, and doctors who continue to think of it as a nutrient.

Or, is this epidemic actually due to excess vitamin D consumption, and the immunosuppressive effects of 25-D on people infected with L-form bacteria?

The addition of even more vitamin D to the food supply will, without a doubt, continue to raise the average person’s level of 25-D well past the point at which it becomes immunosuppressive.


That link is a big read, haven't read it all yet but just thought I'd post it as there seems so little about that actually argues against this so called wonder vitamin... or should I call it steroid.
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Re: Possible 75% cancer mortality reduction with Vitamin D

Postby cleaver on Sun Jan 24, 2010 10:35 pm

Has NU stolen your log in details Bison :lol: :lol:

Vit D does have a very similar structure to anabolics ;)
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Re: Possible 75% cancer mortality reduction with Vitamin D

Postby Dtlv74 on Sun Jan 24, 2010 11:05 pm

5.The public does not require extra sun exposure in order to prevent vitamin D “deficiency.”


This is very true - in bright sunshine the body can produce upto 15,000 IU in just two - three mins.

Vit D supplementation looks ok to me, although haven't tried it yet. Have seen a study on medium-long term exposure to high doses (two years at 7,500IU daily if i remember right) that showed no negative impact on any tested markers at all.

Personally am interested in it as a bit of an experiement and am satisfied it's safe (safer than a macro imbalanced diet for example ;) )

11.Research touting vitamin D’s benefits is often biased, methodologically weak, and ultimately misleading.


But the quality of these studies is equal to the quality of all other studies - including those that offer counter arguments :mrgreen:
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Re: Possible 75% cancer mortality reduction with Vitamin D

Postby health4ni on Wed Feb 24, 2010 3:39 pm

An article from Charles Poliquin:

http://www.charlespoliquin.com/ArticlesMultimedia/Articles/Article.aspx?ID=230
Vitamin D3: Best...Supplement...Ever!

The facts about one of the greatest discoveries in functional medicine
by Charles Poliquin

An osteopathic physician recently asked me, “What’s with all this hype over vitamin D3?” It was a good question. There have been countless supplements, especially in the field of bodybuilding, that have failed to live up to their promises. I remember when the next big things were AKG, vanadyl sulfate and boron (which, incidentally, is the primary ingredient in 20 Mule Team Borax!). But vitamin D3 is the real deal. Write this down:

“Vitamin D3 may be the single most important supplement we can take for our health.”

I’m serious! Fish oil also has amazing properties, but it takes a backseat to vitamin D3. Listen, I get a lot of feedback from the field. I hear from experts from all over the world. There is consensus among the best practitioners: They have verified over and over that just about everyone is deficient in vitamin D3 and that supplementation is essential.

The evidence is indisputable. The scientific literature is overwhelmed with data that confirm what all these experts have seen. I see the truth of it every day and have been teaching about the importance of vitamin D3 supplementation for some time now. The bottom line is that virtually every disease and adverse health condition is associated with low vitamin D3 levels. Consequently, many of these problems may be fixed with adequate vitamin D3 supplementation, or can be avoided by keeping vitamin D3 levels in the high normal range.

For a long time vitamin D3 was simply regarded as the anti-rickets and bone health vitamin – an underwhelming bit of knowledge. Because it was originally labeled as a vitamin, it was assumed that it wasn’t that important. Now it is more properly recognized as a prohormone that is essential to life. Even if it were only good for bone health, vitamin D3 still would be an important supplement, but the benefits go way beyond just bone health.

Let’s look at this in another way. What if a big pharmaceutical company made a revolutionary breakthrough and announced they had come across a compound so important that it could improve the lives of virtually everyone in the world? What if they told us that for less than 20 cents a day (or about 0.15 Euro) we could significantly reduce our risk for some of the most widespread diseases? What if they also announced that the side effects were actually good and that we would receive all these benefits without any real risk of adverse conditions? And that we wouldn’t even need governmental intervention to make it affordable? The answer is that this would be the biggest blockbuster drug ever to hit the market. Everyone would want a prescription and wouldn’t even mind paying for it themselves.

I’d like you to consider some of the research and benefits and make your own decision. Don’t just skim this; read through it and understand what’s being said in the research. The two best sources I’ve found have compiled a tremendous amount of research and information: http://www.vitamindcouncil.org (click on “research” on the left and you will be amazed) and http://www.vitamindhealth.org (Dr. Michael Holick’s website). But to get you started, here are some excellent, peer-reviewed articles.

1. Rickets, bone density, osteoporosis, osteopenia, osteomalacia: Low levels of vitamin D contribute to osteopenia and fractures. JAMA. 2002;287:3127-3129.

2. Fetal brain development and maternal health: Med Hypotheses. 2010 Jan;74(1):71-5. Epub 2009 Aug 18.

3. Psoriasis: “Hyperproliferative skin disorders such as psoriasis might be responsive to treatment with vitamin D....” “[Treatment with vitamin D] …showed great improvement in reducing the severity and area of psoriatic lesions.” Holick, MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clinic Proceedings. 2006 Mar;81(3):353-73.

4. Cancer: “Both prospective and retrospective epidemiologic studies indicate that levels of 25-OH D below 20 ng [nanograms] per milliliter are associated with a 30 to 50% increased risk of incident colon, prostate, and breast cancer, along with higher mortality from these cancers....” “Vitamin D either directly or indirectly controls more than 200 genes, including genes responsible for the regulation of cellular proliferation, differentiation, apoptosis, and angiogenesis.” Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

5. Blood sugar regulation and insulin resistance: “Vitamin D deficiency increased insulin resistance, decreased insulin production, and was associated with the metabolic syndrome.” Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

6. Depression and other neurological concerns: “Several studies suggest an association between hypovitaminosis D and basic and executive cognitive functions, depression, bipolar disorder, and schizophrenia.” Curr Psychiatry Rep. 2009 Feb;11(1):12-9.

7. Multiple Sclerosis: “High circulating levels of vitamin D are associated with a lower risk of multiple sclerosis.” JAMA. 2006;296:2832.

8. Immune function: “When serum levels of 25-hydroxyvitamin D fall below 20 ng per milliliter, the monocyte or macrophage is prevented from initiating this innate immune response” Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

9. Cold, flu, and respiratory tract infection: shortened duration of symptoms in study of African women.

10. Symptoms associated with autoimmune conditions: Vitamin D deficiency affects the immune system’s capacity to self-regulate and can therefore lead to tissue damage via overproduction of potentially pathogenic cytokines.

11. Hypertension and congestive heart failure: “In a study of patients with hypertension who were exposed to ultraviolet B radiation three times a week for 3 months, 25-OH D levels increased by approximately 180% and blood pressure became normal.” “Vitamin D deficiency is associated with congestive heart failure.” Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

12. Muscle mass and strength
: “Vitamin D deficiency causes muscle weakness.” “Performance speed and proximal muscle strength were markedly improved when 25-hydroxyvitamin D levels increase from 4 to 16 ng per milliliter (10 to 40 nmol [nanomole] per liter) and continued to improve as the levels increase to more than 40ng per milliliter (100 nmol per liter). Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

13. Weight Loss: “For every increase of 1 ng/mL in level of 25-OH D3, subjects ended up losing almost 0.2 kg more on their calorie-restricted diet.” Shalamar Sibley, prepublication report for the Endocrine Society’s 91st Annual Meeting.

14. And even longevity, epilepsy, Alzheimer’s, thyroid conditions…

...and this just scratches the surface of the research!

Now the question becomes “How do I get my vitamin D3 to optimal levels?” This is the best part, since it’s very easy to fix vitamin D3 deficiency. There are a couple of different approaches that have been shown to work very well. One way is to just supplement with 5,000 IU of vitamin D3 every day and it’s likely your levels will be at least in the normal range within about three months, but remember, high normal is better than mid normal. Expect it to take another couple of months to reach high normal.

Another approach, which I prefer, is to supplement twice per week with about 30,000 to 100,000 IU of D3. Based on the research and clinical evidence, this method seems to accelerate the increase in blood levels of 25(OH) D3 (the marker that should be tested for). Although the kidneys still need to convert 25(OH) D3 into 1.25(OH)2 D3, the relevant lab value is 25(OH) D3. You should be shooting to get your levels between 80 and 100 ng/mL.

Now let’s go back to our “what if” scenario and ask the question again: What if there were one natural supplement that had been shown in scientific research to improve bone health, improve the development of babies’ brains, reduce the incidence of skin problems like psoriasis, prevent or remedy multiple sclerosis, reduce the risk of cancer, improve blood sugar levels and reduce insulin resistance, improve neurological conditions including depression and bipolar disorder, enhance immune defense against cold, flu and other infections, lower blood pressure and protect the heart, improve muscle function, increase the ability to lose bodyfat and even help people live longer? What if that compound existed and could be manufactured properly at a very affordable price? I’m happy to give you an answer that is not hypothetical and that you can believe: Vitamin D3 is, literally, the best supplement ever!
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