Ecdysterone

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Ecdysterone

Postby health4ni on Fri May 29, 2009 8:50 am

Ecdysterone, aka 20-Hydroxyecdysone, extracted from the plant Rhaponticum carthamoides is a very powerful non-hormonal anabolic agent... apparently. Anyone used it? Heard of it? etc etc
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Re: Ecdysterone

Postby simon m on Fri May 29, 2009 8:53 am

health4ni wrote:Ecdysterone, aka 20-Hydroxyecdysone, extracted from the plant Rhaponticum carthamoides is a very powerful non-hormonal anabolic agent... apparently. Anyone used it? Heard of it? etc etc

Heard of it and from what I recall that in real world situations it has little or no value, but this is only a recollection. Will have a look into this when at home.
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Re: Ecdysterone

Postby GymBunny on Fri May 29, 2009 9:03 am

I have heard of it, only because I was doing some research into rodiola rosea.

I saved some info on it

Introduction: Rhaponticum carthamoides (Willd) Ijin, also know as Leuzea, or Maral root, is plant indigenous to the Lake Baikal region and distributed throughout Eastern Siberia. Traditionally the Siberians consumed the Leuzea tea mixed with Rhodiola rosea root for a long time as a natural stimulant, in cases of tiredness and general weakness after illness and energizing remedy after the long Siberian winter...

Phytochemistry: Key active constituents responsible for specific anabolic effect of Rhaponticum carthamoides is a mixture of compounds called, "levseins". Levseins represents a complex of more than 10 ecdysterones including 20-beta-ecdysterone, makisterone C, 24-dehydromakisterone A, carthamosterone, polypodyne B and ajugasterone C.

Pharmacology: According to Russian researchers the Leuzea extract stimulates muscle protein synthesis by increasing the activity of the polyribosomes. Polyribosomes are the cellular compartments where the actual protein synthesis takes place. Researchers extracted and purified various ecdysteroids from Leuzea and found that the ecdysteroids increased the mass of the developing quails in a dose-dependent manner, with the rate of increase proportional to the ecdysteroids content. It was evident that the plethora of growth-promoting, vitamin-like effects induced by Leuzea is mediated by ecdysteroids.

However it is important to point out that the mixture of ecdysterones was found to be responsible for enhancement of muscle protein synthesis. The research indicated that the whole extract of Rhaponticum carthamoides containing mixture of levseins possess much superior physiological activity compared with the activity of purified individual constituents (Seifulla 1999). Results indicated that 0.5mg/kg body weight is the optimal dosage of 20-beta-ecdysterone in any sport and performance formula.

Rhaponticum carthamoides - A Powerful Natural Anabolic Back in the '70s, the Soviet sports teams were caught using numerous steroids. In 1976 Soviet scientists discovered two substances that had traditional historical use behind them. One was a plant called Rhaponticum carthamoides, the active ingredient of which is called beta-ecdysterone. The Soviets manufactured a synthetic version of this powerful substance for their athletes with great success. Soon after, the U.S. version called Mesobolin circulated on the underground market for a long time. In back-to-back studies with animals, the Rhaponticum extract was actually superior to synthetic steroids like Dianabol at inducing endurance and muscle cell growth (Syrov et al. 1976, 1992).

The examination of the difference in action between beta-ecdysterone and synthetic steroids revealed that the latter go directly to the nucleus of a cell to tell the blueprint, the DNA, to produce more RNA. Then the RNA tells the ribosome to produce more protein. Beta-ecdysterone, on the other hand, goes directly to the ribosome and increases what is called translation, the rate at which new protein is being made (Syrov et al. 1984)...


I just tried to find the original source I saved that from but it doesn't appear to be on the web anymore. Source was http://www.rhodiolarosea.org/Web-Rhaponticum.pdf
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Re: Ecdysterone

Postby GymBunny on Fri May 29, 2009 9:06 am

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Re: Ecdysterone

Postby Alex on Fri May 29, 2009 10:57 am

From what I recall this is a similar supplemt to Methoxy Isoflavone which is flawed due to having a very short half life and doesn't raise blood NO2 levels for long enough to promote an increase in Protein Synthesis. I think it's a similar set of circumstances with Beta Ecdysterone as well.

Having said that I did notice some very subtle strength and mass gains when using Methoxy Isoflavone but you could easily put these down to placebo. I noticed far more benefit from using OKG to be honest.
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Re: Ecdysterone

Postby health4ni on Fri May 29, 2009 12:31 pm

Thanks for the info guys & girl. I'll read in detail later.

Seems to have been a popular Russian supp. Also seems that Ecdysterone from Rhaponticum carthamoides variety is the best, and also if it has a high % of active ingredients (like 95%).
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Re: Ecdysterone

Postby julesm on Fri May 29, 2009 1:13 pm

do a search stateside brother
as mentioned pathways look phenomenal on paper, just dont think it transpires to real world results, but it certainly is a supp that doesnt die
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