Alex wrote:

kp1512 wrote:sharing the wealth and all that...seemed a good site - prices good?

http://bigvits.co.uk/products.asp?cid=68" onclick="window.open(this.href);return false;" onclick="window.open(this.href);return false;

£35 vs $15...

kp1512 wrote:

Dtlv74 wrote:Am gonna get me some and dose at 10,000IU daily for the rest of the winter - will drop the dose down when the spring time hits. The research on vit D(3) is pretty compelling.

why so high?

Alex wrote:Lack of sunlight exposure during the winter months - 10000 during winter and 5000 during.

Dtlv74 wrote:

kp1512 wrote:

Dtlv74 wrote:Am gonna get me some and dose at 10,000IU daily for the rest of the winter - will drop the dose down when the spring time hits. The research on vit D(3) is pretty compelling.

why so high?

Alex wrote:Lack of sunlight exposure during the winter months - 10000 during winter and 5000 during.

Exactly as Alex says .

Also, as you guys know already I have both depression and sleep issues at times, and this dose of D3 is regarded as the best dose for helping with these issues. No danger of toxicity so why not?

Dr Young wrote:The Right Fats

The assimilation and utilization of vitamin D is influenced by the kinds of fats we consume. Increasing levels of both polyunsaturated and monounsaturated fatty acids in the diet decrease the binding of vitamin D to D-binding proteins.

Saturated fats, the kind found in butter, tallow and coconut oil, do not have this effect. Nor do the omega-3 fats.1

D-binding proteins are key to local and peripheral actions of vitamin D. This is an important consideration as Americans have dramatically increased their intake of polyunsaturated oils (from commercial vegetable oils) and monounsaturated oils (from olive oil and canola oil) and decreased their intake of saturated fats over the past 100 years.

In traditional diets, saturated fats supplied varying amounts of vitamin D. Thus, both reduction of saturated fats and increase of polyunsaturated and monounsaturated fats may contribute to the current widespread D deficiency.

Trans fatty acids, found in margarine and shortenings used in most commercial baked goods, should always be avoided. There is evidence that these fats can interfere with the alkaline buffering systems the body uses to convert vitamin D in the liver.2

1. Bouillon R, Xiang DZ, Convents R, Van Baelen H. Polyunsaturated fatty acids decrease the apparent affinity of vitamin D metabolites for human vitamin D-binding protein. J.Steroid Biochem.Mol.Biol. 1992;42:855-61.

2. Enig, Mary G. Modification of Membrane Lipid Composition and Mixed-Function Oxidases in Mouse Liver Microsomes by Dietary Trans Fatty Acids. 1984. University Microfilms International. Ann Arbor, Michigan.

A bright spark on another forum wrote:Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. An Overview of Cholecalciferol Toxicosis. The American Board of Veterinary Toxicology (ABVT).

This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules. Vieth reports human toxicity probably begins to occur after chronic daily consumption of approximately 40,000 IU/day.

cleaver wrote:

A bright spark on another forum wrote:Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. An Overview of Cholecalciferol Toxicosis. The American Board of Veterinary Toxicology (ABVT).

This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules. Vieth reports human toxicity probably begins to occur after chronic daily consumption of approximately 40,000 IU/day.

cleaver wrote:

A bright spark on another forum wrote:Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. An Overview of Cholecalciferol Toxicosis. The American Board of Veterinary Toxicology (ABVT).

This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules. Vieth reports human toxicity probably begins to occur after chronic daily consumption of approximately 40,000 IU/day.

Resurrected wrote:

cleaver wrote:

A bright spark on another forum wrote:Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. An Overview of Cholecalciferol Toxicosis. The American Board of Veterinary Toxicology (ABVT).

This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules. Vieth reports human toxicity probably begins to occur after chronic daily consumption of approximately 40,000 IU/day.

At certain doses (based on bw) chocolate is poisonous to canines due to the theobromine in it. Does that mean it will kill the average homo-sapien? So as per usual you can take anything out of context and create some BS.

An article published online on November 7, 2009 in the journal Breast Cancer Research and Treatment reveals the discovery by scientists at the University of Michigan Comprehensive Cancer Center that curcumin, a compound derived from the spice turmeric, and piperine from black pepper help inhibit the growth of stem cells that fuel breast cancer.

Stem cells are unspecialized cells that can develop into any type of cell in a particular organ. In their introduction to the article, University of Michigan Medical School clinical lecturer Madhuri Kakarala, MD, PhD, RD and colleagues explain that "The cancer stem cell hypothesis asserts that malignancies arise in tissue stem and/or progenitor cells through the dysregulation or acquisition of self-renewal." According to this hypothesis, the recurrence of cancer after chemotherapy is due to the drugs' ineffectiveness against cancer stem cells. Accordingly, eliminating cancer stem cells and reducing the amount of normal stem cells could decrease cancer risk.

The researchers compared the effects of varying concentrations of curcumin and piperine, alone and in combination, to a control substance administered to cultured breast epithelial cells. The amounts of curcumin and piperine employed were the equivalent of approximately 20 times the potency of what could be consumed through one's diet. They found a reduction in markers for breast stem cells in cultures treated with the lowest concentration of curcumin, and complete inhibition at twice that concentration. Piperine also demonstrated an inhibitory property, although the effects were not as pronounced as those elicited by curcumin. However, the addition of piperine to curcumin resulted in a reduction in stem cells that was greater than either agent alone, while having no effect on normal cell development or viability. “This shows that these compounds are not toxic to normal breast tissue,” Dr Kakarala remarked.

The report is the first to conclude that curcumin and bioperine could help prevent cancer by targeting stem cells. This mechanism has the potential to prevent estrogen-sensitive tumors as well as more aggressive non-estrogen dependent cancers.

“If we can limit the number of stem cells, we can limit the number of cells with potential to form tumors,” Dr Kakarala noted. “Women at high risk of breast cancer right now can choose to take the drugs tamoxifen or raloxifene for prevention, but most women won’t take these drugs because there is too much toxicity. The concept that dietary compounds can help is attractive, and curcumin and piperine appear to have very low toxicity.”

From http://www.lef.org/newsletter/2009/1215 ... rticle&l=0" onclick="window.open(this.href);return false;

Alex wrote:Aren't tomato's meant to be good as well? Not sure what it is they contain though that would make them so.

kp1512 wrote:good post - was going to put something up about this...so far id say

I3C
Grape Seed
Pome Extract
Curcumin
green tea
Na rala
resvertrol
cq10

id say put them in a cap in loweramounts each and you have created a very credible anti ox, preventative product.

missed anything? just trying to think which other products would be a good addition

health4ni wrote:it'll cost so much.

health4ni wrote:

kp1512 wrote:good post - was going to put something up about this...so far id say

I3C
Grape Seed
Pome Extract
Curcumin
green tea
Na rala
resvertrol
cq10

id say put them in a cap in loweramounts each and you have created a very credible anti ox, preventative product.

missed anything? just trying to think which other products would be a good addition

DIM is probably a better bet than I3C; less reactive (in a negative way), and less absorbable than DIM.

Great list though for sure. I'd personally leave out the green tea. Maybe add some t ocotrienols (Vit E).

Question is: do any compete with each other?

Plus, it would be one very big tablet or you'd have to take a few of them...