Alex wrote:Are you sourcing from UK?

Alex wrote:Ordered and arrived this morning so will give this a run for 2-3 months pre and during workout.

Craig wrote:

Alex wrote:Ordered and arrived this morning so will give this a run for 2-3 months pre and during workout.

What dose are you going with and what are you mixing it with out of interest?

health4ni wrote:So Peptopro is hydrolysed right?

Doesn't hydrolysed protein cause glutamate to become separated from the protein (as it were)?
And free glutamate is a known excitotoxin; and can be toxic to the neurons of the brain, and the entire nervous system. It is free glutamate which makes the infamous food additive MSG (or monosodium glutamate) so dangerous.

So, hydrolysed whey & casein and presumably Peptopro has free glutamate? Or results in free glutamate to be circulating around the body when ingested?

Some serious bro science being dropped there. A true mess of misinformation on glutamic acid, protein and amino-acid metabolism in general. You can usually tell by looking at many of the references, or lack there of on these websites to get an idea of the quality of info. These sites and I have seen a few, basically pick on glutamate, aspartate and glutamine. Regardless, the emphasis, as irrelevant as it is, should be on the free-form amino acids, glutamic acid, glutamine, aspartic acid, histidine, arginine and proline, not hydrolyzed protein, most having little to no free-form amino acids.

Anyway, yes, certain amino-acids are classified as excitatory( depolarization) or inhibitory(hyperpolarization) on neurons, a totally normal and necessary process in physiology. Glutamate, aspartate and others can act as excitatory neurotransmitters in the body, heck even extracellular calcium causes depolarization(.. again, totally normal and necessary, yet another thing that many of these websites go on about. Other neurotransmitters like norephephrine is also excitatory, as is dopamine(though it can be inhibitory as well). Anyway, the list goes on and on.

What these scare sites always fail to mention besides all the obvious, is that glutamate or aspartate is used in our bodies for many different functions besides as neurotransmitters, such as carriers of waste nitrogen, used in the krebs cycle, used to make other amino-acids or how they are glucogenic(catabolized to produce glucose). They often fail to mention or make the connection that there are other amino-acids our bodies use to make glutamate..arginine, glutamine, histidine and proline. Heck the conversion of glutamine to glutamate only takes one reaction, using the enzyme glutaminase. So be worried about free form glutamine as well!

They also fail to mention there is high levels of naturally occurring free glutamate in all kinds of vegetables such as tomatoes, grapes, mushrooms.

They say, glutamate OVER excites nerves but compared to WHAT and at what dose? Where is the research in healthy humans, that glutamate, aspartate or glutamine causes damage? Sure in people with certain neurodegenerative diseases, they may want to avoid certain foods with high glutamate, MSG or other amino-acids, sugars or allergens in them but these popularities often have very different diets anyway, low carb high protein, vice versa, ect, ect.

If you are really that scared about ingesting these naturally occurring amino-acids, then you will need to avoid pretty much any protein powder that has the above free form amino acids, especially glutamine and aspartic acid. You will also need to avoid many vegetables

I think this is a legitimate concern that deserves more attention. everyones should know what they are putting into their body's...especially on a website such as this. due to the fact that hydro is predigested (containing free amino acids), it has free glutamate/glutamic acid. this free glutamate is an EXCITOTOXIN meaning its overexcited CNS neurons to the point of death. now, this is MUCH different than taking regular protein with glutamate in it becuase the protein is bound and digested in a slow manner(no over excitement). Well, it's one thing when the body itself has to break down the protein into amino acids - it metabolizes as much of the protein it needs. But, it's a different thing when you ingest large amount of free protein and force the body to uptake all of the proteins in a form already available for use. this can have long term effects (although no long term studies yet) similar/identical to msg. the large problem i see is that in many post workout products, we ingest 20-30g of hydrolyzed whey, not to mention more in many added protein. please discuss as i hope someone proves me wrong (for real).

there are many papers wrote on this (sadly many very biased and scare-tactic-like, but i think this deserves attention since we consume hydro in such large amounts and the science behind the facts i have given you is proven).

do you have any study that shows what you`re saying?

it is common knowledge that glutamate is an excitotoxin. however, you wont find any studies on the long term effects on this. theres no doubt it is bad for you though. the fda wont get inlvolved (maybe in the future) becuase they dont regulate supplements and they're not taking a stance on the whole msg deal.

there are a ton of articles written by this and the fda (pretty sure although not 100%) does admit there is "msg" in hydrolyzed proteins. the thing is we take in such a large amount of hydro in some supps.

truthinlabeling.org/hiddensources
truthinlabeling.org/manufac

this second one is especially good.

Doesn't Optimum nutrition's gold standard have hydro whey?

yes but in VERY small amounts.

Hmmm,is this why the guys at True protein recommend only taking 10grams of PeptoPro???

MSG is a toxic substance people consume in processed foods, and probably wouldn't if they knew it causes many of their brain cells to die. MSG is an excitotoxin -- a chemical transmitter that causes your brain cells to overwork themselves until they die.