Na-RALA

by **Craig** on Fri Sep 26, 2008 11:51 am

Is this stuff dose dependent?

Will taking 500mg after a meal have 5 time the effect of 100mg or is there a limit?

by **Marks1972** on Fri Sep 26, 2008 12:19 pm

Doesnt too much have a similar effect as a diabetic going low sugar?

by **Craig** on Fri Sep 26, 2008 12:21 pm

Marks1972 wrote:Doesnt too much have a similar effect as a diabetic going low sugar?

Yep thats what I'm asking, will 10 tabs do it and 1 not, will 2 tabs be twice as strong as one etc

by **health4ni** on Fri Sep 26, 2008 12:29 pm

I don't have a confirmed answer. But I think it is dose dependent. I think 200mg is twice as "powerful" as 100mg. I think.

by **Craig** on Fri Sep 26, 2008 12:34 pm

health4ni wrote:I don't have a confirmed answer. But I think it is dose dependent. I think 200mg is twice as "powerful" as 100mg. I think.

Is it tissue specific in its insulin mimic action or will it store in BF as well as muscle?

by **julesm** on Fri Sep 26, 2008 12:45 pm

i think there is a lot of related questions over on anabolicminds regarding this matter- people asked the question of taking na-rala against P-slin (?) and the tissue specificity of each product.

by **Craig** on Fri Sep 26, 2008 12:56 pm

julesm wrote:i think there is a lot of related questions over on anabolicminds regarding this matter- people asked the question of taking na-rala against P-slin (?) and the tissue specificity of each product.

No real answer then :mrgreen:

I'm thinking of using it after dieting down to a low BF as part of a rebound cycle.

by **julesm** on Fri Sep 26, 2008 12:57 pm

trying to find it for you- lazy arse
search function on anabolic minds

by **simon m** on Fri Sep 26, 2008 1:05 pm

Craig wrote:
julesm wrote:i think there is a lot of related questions over on anabolicminds regarding this matter- people asked the question of taking na-rala against P-slin (?) and the tissue specificity of each product.

No real answer then

I'm thinking of using it after dieting down to a low BF as part of a rebound cycle.

I've got some and will be taking after each meal containing carbs and post workout. Will let you have my thoughts in a month.

by **julesm** on Fri Sep 26, 2008 1:08 pm

sorry my mistake- wasnty p-slin but some product called anabolic pump.
here is what i have lifted from their representative:

Na-RLA works through Insulin-dependent pathways, whereas AP utilizes Insulin-reactive pathways - this differentiates the two, in terms of the selectivity of their glucose disposal. Plus, last time I checked, Na-RLA didn't mitigate AMPk, or downregulate PPAR Gamma mRNA expression

The only issue is Insulin release: Na-RLA and likewise supplements illicit such a response, whereas AP does not. This is advantageous in a body recomposing effect, insofar as upregulating catabolic response in adipose (producing energy for cellular reactions) and anabolic response in muscle tissue (providing mitochondria with cellular energy to repair tissue).

by **Craig** on Fri Sep 26, 2008 1:17 pm

The basic info on NA-RALA always states that it mimics insulin, yet there it says that it increases your insulin response. I'm confused and there seems to be feck all info on the stuff!

As for USP and anabolic dump........... they just seem shady to me.

by **julesm** on Fri Sep 26, 2008 1:23 pm

i'd opt for the one that works through insulin dependent pathways- ie na-rala.

as regards dosage- i think it is dose dependant 100mg for every 40g of carbs (?) so it would be overkill to take 500mg if you only ingested 40g of carbs, plus you'd have a pretty horrendous hypo episode- headaches, nausea, faintness, tremors.

by **Craig** on Fri Sep 26, 2008 1:29 pm

julesm wrote:i'd opt for the one that works through insulin dependent pathways- ie na-rala.

as regards dosage- i think it is dose dependant 100mg for every 40g of carbs (?) so it would be overkill to take 500mg if you only ingested 40g of carbs, plus you'd have a pretty horrendous hypo episode- headaches, nausea, faintness, tremors.

I want to use it to bulk so I want the maximal insulin response, now as you'd know (?) if using exogenous insulin you'd take it after the meal to get your own insulin response plus the exogenous supply. This is why I wonder if it increases or replaces your endogenous supply. I'm not carb sensitive at all, can quite happily bang them away, in fact its essential for any kind of growth.

by **kp1512** on Fri Sep 26, 2008 1:52 pm

Id agree 100mg for 30-50g Carbs - but dont do what I did for the sake of testing take 600mg on an empty stomach...not good.

by **Dtlv74** on Mon Oct 06, 2008 3:51 pm

My understanding is that ALA/thiocitic acid does work on the insulin dependent pathway but not just by increasing insulin alone - it kind of 'tweaks' and upregulates the efficiency of the other cofactors (such as GLUT 4 action and pyruvate etc). Not quite the info asked for in this thread but this might help a little:

Abstract: Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation?

ImmuneSupport.com
08-31-2005
Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):1032-9.

Konrad D.

Division of Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland. daniel.konrad@kispi.unizh.ch

Alpha-lipoic acid is a naturally occurring cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant. It can interchange between a reduced form and an oxidized form, thereby displaying reducing (antioxidant) and prooxidant properties, respectively.

It is suggested that alpha-lipoic acid through its prooxidant properties acutely stimulates the insulin-signaling cascade, thereby increasing glucose uptake in muscle and fat cells. On the other hand, alpha-lipoic acid appears to protect the insulin-signaling cascade from oxidative stress-induced insulin resistance through its reducing capacities. In addition, alpha-lipoic acid seems to inhibit hepatic gluconeogenesis by interfering with fatty acid oxidation, as well as to increase peripheral glucose utilization by activating pyruvate dehydrogenase resulting in increased glucose oxidation. These different properties render alpha-lipoic acid a potentially attractive therapeutic agent for the treatment of insulin resistance.

Moreover, given the potential role of oxidative stress in the pathogenesis of secondary complications in diabetes, alpha-lipoic acid might be beneficial in the prevention/treatment of these complications as was recently shown for diabetic neuropathy.

PMID: 15998258 [PubMed - in process]

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