Grape Seed Extract

by **simon m** on Tue Sep 08, 2009 11:18 am

Grape Seed Extract is something I used to use and stopped because I ran out of the caps and was too lazy to buy some more, but as I get older and become more worried about estrogen in the water, living with women and having once watched Loose Women, I think it's time to get back on the GSE.

Here's some stuff I've found on the net:

This is from a thread on Bodybuilding.com See: (http://forum.bodybuilding.com/archive/i ... 17561.html)

Here's some cool stuff on GrapeSeedExtract (Procyanidin), from various human, in situ, in vitro, and in vivo studies:

• Inhibits the Aromatase Enzyme (prevents testosterone from converting to estrogen at the genetic level, preventing both transcription and expression of Aromatase) [1-4]

• Acts similarly to Letrozole (a prescription Aromatase Inhibitor), and can destroy breast tumor tissue (gynecomastia) [1]

• Has anabolic properties (Inhibits the Glucocorticoid Receptor, thus allowing more muscle to be built)[4]

• Has Anti-Hypertensive properties [5]

• Improves Cognitive Function [5]

• Lowers LDL Cholesterol [6]

• Is a strong Anti-Oxidant (stronger than vitamin C or E) [6]

. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun 1;66(11):5960-7.

2. Suppression of Estrogen biosynthesis by procyanidin dimmers in red wine and grape seeds. Cancer Res. 2003 Dec 1;63(23):8516-22.

3. Suppression of aromatase (estrogen synthetase) by red wine phytochemicals. Breast Cancer Res. Treat., 67: 133-146, 2001

4. Modulation of aromatase gene expression by grape seed extract. Ikuko Kijima, et al. City of Hope, Durante, CA.

5. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R771-5.

6. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr. 2006 Jul;84(1):252-62.Am J Clin Nutr. 2006 Jul;84(1):252-62.

PLUS

PubMed

Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression.Kijima I, Phung S, Hur G, Kwok SL, Chen S.
Department of Surgical Research, Beckman Research Institute of the City of Hope, Duarte, California, USA.

Aromatase is the enzyme that converts androgen to estrogen. It is expressed at higher levels in breast cancer tissues than normal breast tissues. Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown in our laboratory to be potent inhibitors of aromatase. In this study, GSE was found to inhibit aromatase activity in a dose-dependent manner and reduce androgen-dependent tumor growth in an aromatase-transfected MCF-7 (MCF-7aro) breast cancer xenograft model, agreeing with our previous findings. We have also examined the effect of GSE on aromatase expression. Reverse transcription-PCR experiments showed that treatment with 60 mug/mL of GSE suppressed the levels of exon I.3-, exon PII-, and exon I.6-containing aromatase mRNAs in MCF-7 and SK-BR-3 cells. The levels of exon I.1-containing mRNA, however, did not change with GSE treatment. Transient transfection experiments with luciferase-aromatase promoter I.3/II or I.4 reporter vectors showed the suppression of the promoter activity in a dose-dependent manner. The GSE treatment also led to the down-regulation of two transcription factors, cyclic AMP-responsive element binding protein-1 (CREB-1) and glucocorticoid receptor (GR). CREB-1 and GR are known to up-regulate aromatase gene expression through promoters I.3/II and I.4, respectively. We believe that these results are exciting in that they show GSE to be potentially useful in the prevention/treatment of hormone-dependent breast cancer through the inhibition of aromatase activity as well as its expression

by **Alex** on Tue Sep 08, 2009 12:10 pm

The water isn't an issue at the moment. I saw a program on this fairly recently testing water from all the Water Boards throughout the UK and the levels were virtually nil.

by **Rab** on Tue Sep 08, 2009 12:36 pm

Grape seed extract isnt what you need saimon, its a more alkaline diet with greens drinks

That will sort all your problems and fix your ankle to as good as it was in your early 20's

by **health4ni** on Tue Sep 08, 2009 12:37 pm

@Alex: you think it's more of an issue USA?

Also, it does depend on who tests it and how good their testing equipment is.

Drinking from plastic bottles doesn't help... but I also think that it's only a problem when you drink hot water from it as that will cause the plastic to leech off the side.

by **Alex** on Tue Sep 08, 2009 12:48 pm

The tests were done both by the Water Boards themselves and by an independant tester to make sure the results weren't being fixed and both came up pretty much the same. I'd imagine the equipment would be decent enough, especially from the independant which was University based although I forget which one. But we can't know for sure.

Usually the USA is stricter on what levels they allow than EU which is especially evident in the yearly allowance of Farmed Salmon for an individual; About 3-4 500g servings for USA vs about 40 500g servings for EU. One would therefore assume that they would be as strict with drinking water but I honestly don't know.

Too many assumptions unfortunately.

by **Dtlv74** on Tue Sep 08, 2009 7:14 pm

Simon, am sorry to hear that you once watched an episode of Loose Women - I know such things can be pretty traumatic. If you ever need any support PM me mate.

by **RoB** on Tue Sep 08, 2009 7:29 pm

Fat is your worst enemy when it comes to estrogen. Fat is the primary site of aromatization of testosterone into estradiol (the most potent of endogenous estrogons), the fatter you are the more testosterone is aromatized. It's why leaner people suffer less from gyno when on cycle. I'm really scepticle about phytoestrogens and how much of an effect they actually have.

by **Dtlv74** on Tue Sep 08, 2009 9:15 pm

Have been reading about phyto oestrogens recently and many of them have only actually demonstrated definite effects on birds and a few species of mammals - in humans it's far less clear cut with no clear evidence that they have any significant impact on aromatization in those who are healthy. Most of the evidence suggests their impact on aromatization is specific to those who already have some form of cancer, with some phyto oestrogens seeming to be beneficial and some to be detrimental.

GSE is one that, in the studies that have looked at it, appears to be at the worst harmless and at best something that does help prevent cancer related aromatization and accelerates cancer cell death.

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