Sup doods,

Just wondering if anyone has a good legitimate source, or any personal experience with this stuff. Any results in weight-lifter populations?

I am researching it for purchase reasons.

Cheerios

Yes there is......a fair few....ill get some up later....if you dont already find em

so farrrrrrrrrrrrrrrrr.....
Ok here is what I am finding:

Plant harvested in parts of India in warmer climates

Potential Research Roles:
Antioxidant and Antimicrobial Activity of Cissus quadrangularis L

Extracts of Cissus quadrangularis L. were tested for antioxidant activity by β-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the β-carotene linoleic acid system and 61.6% in the 1,1-diphenyl-2-picrylhydrazyl system. This fraction showed the presence of sterols, vitamin C, and tannins as phytoconstituents. The antioxidant activity of methanol extract and aqueous extract were comparatively less significant than that of ethyl acetate extract, and n-hexane extract showed the least activity. The ethyl acetate extract and methanol extract of both fresh and dry stems further exhibited antimicrobial activity against Gram-positive bacteria, including Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Streptococcus species. The results of the study have implications in the use of C. quadrangularis as an antibacterial agent and more so as an antioxidant in several applications requiring these properties.

Several of the studies relate to enhanced Fracture healing dating back to the 60’s. Which makes me wonder as I am working on an Orthopaedic Ward at the moment why on earth this stuff isn’t prescribed to patients along with physiotherapy, while they are on concoctions of mind-altering and psycho delirium drugs.

Also I found this which has shed some insight, however, I am wary of because it is unsourced review:


Cissus has a large vitamin component but more importantly the ability to deliver the vitamin to the target tissue.Cissus also stimulates myoblast and osteoblast acitivity. Form my brief studies on Tendons, Osteoblasts and myoblasts stimulate collagen II synthesis. Just because we stimulate collagen II synthesis does not exactly correlate to HEALING of an injury. You can stimulate Collagen II synthesis and GROW NEW tissue. New tissue is great if its directly stimulated where injury occurs. You can stimulate new growth but the growth may be away from the injury. A great example is your brick wall has a whole in it and instead of patching the whole directly you build a NEW wall to over the whole. The structural instability is still present.

Cissus in research has proven to correct structural instability in fractures. The healing process of Fractures includes Tendon and ligament stability.

THE SCIENCE
Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. It was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. Modern research has shed light on Cissus' ability to speed bone healing by showing it acts as a glucocorticoid antagonist (1,2). Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing, it has been postulated that Cissus possesses anabolic and/or androgenic properties (1,3). In addition to speeding the remodeling process of the healing bone, Cissus also leads to a much faster increase in bone tensile strength. In clinical trials Cissus has led to a fracture healing time on the order of 55 to 33 percent of that of controls. That cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakend by treatment with cortisol, and upon administration of Cissus extract the cortisol induced weakening was halted, and the healing process begun.

While the increased rate of bone healing may be of great significance to persons suffering from chronic diseases like osteoporosis (4), the antiglucocorticoid properties of Cissus are likely of much more interest to the average bodybuilder or athlete, since endogenous glucocorticoids, particularly cortisol, are not only catabolic to bone, but catabolize muscle tissue as well. Numerous studies over the years have suggested that glucorticoids, including the body's endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis (5). This pathway of tissue breakdown is important for removing damaged and non-functional proteins. However, when it is overactive during periods of elevated cortisol (e.g disease states, stress, and over-training) excess amounts of normal tissue are broken down as well. By exerting an anabolic, antiglucorticoid effect cissus helps preserve muscle tissue during times of physical and emotional stress.

Although the bulk of the research on Cissus centers around bone healing, the possibility exists that Cissus may act to improve bone healing it may improve the healing rate of connective tissue in general, including tendons. If this is the case it would be of great benefit to bodybuilders and athletes.

Besides the above-mentioned properties of Cissus, the plant is also rich in the vitamins/antioxidants vitamin C and beta-carotene. As analyzed, Cissus quadrangularis contained ascorbic acid 479 mg, and carotene 267 units per 100g of freshly prepared paste in addition to calcium oxalate (6).

The typical recommended daily dosage of Cissus is 3 to 6 gramalso s to accelerate fracture healing. Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So not only is Cissus efficacious, it is quite safe, in either the dried powder form or the commercially available extract.

Cissus also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis, which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins.
Real World Application for injuries

Simply if your suffering from Joint pain, Ligament pain, cartilage pain, had surgery on bone, ligament or cartilage, Cissus is the supplement to use. It has been my experience that many grapplers take anti-inflammatory medications to fight through the pain. Ultimately, these medications only kill the sensation of pain not the symptom. Cissus has the ability to kill the pain specific to the injury while promoting healing.

Some users will get instant relief and other will need to use Cissus for much longer period of time for complete healing of an injury. Leverage performance science is not claiming that Cissus will work 100% percent of the time that would be a foolish claim. We have estimated that 85% of user experience relief from our product. This number may lower or rise as more consumers send in reports. In the PHARMACUETICAL industry a 50% success rate is good. Since we talking about the Pharmaceutical industry, they have yet to produce a product that helps the healing process. They just develop pain medications that are often addicting.

THE OTHER SIDE EFFECT IS ANABOLIC!
Cissus is anabolic and anti-catabolic!!! Cissus users report a "PUMP" that we call the Cissus pump. The PUMP effect becomes prevalent at approximately 10-15 days of continous Cissus use. The "PUMP" is due to the increase of blood flow to the muscle. The Cissus pump will have you flexing your muscle for no apparent reason. This is when you know the product has exerted its effect.

Cissus is a powerful natural anabolic; if not the most powerful natural anabolic on the market. Why would a grappler need it? An Anabolic and anti-catabolic substance allows for faster recovery from exercise, from injury, increase in muscle strength, and stamina. In short, you will be able to train longer and recover faster without the negative effects of anabolic steroids.

Cissus is also an ideal product to use in conjuntion with cAMPED for dropping weight. Imagine decreasing bodyfat while simultaneously retaining your strength and preserving muscle mass while on a calorie restricted diet! The combined effects of Cissus and cAMPED become a powerful tool for any competive grappler!


WARNING
If using Cissus to heal injury related pain, you may experience instant relief due to its analgesic (pain killing) effect . This does not mean the injury has completely healed! Please continue your training regimen with extra caution until full recovery has been achieved. On the contrary, if using Cissus primarily for its Anabolic properties your training program should be continued with maximum intensity to reap the full benefits of this product.

References
1) Chopra SS, Patel MR, Awadhiya RP. Studies of Cissus quadrangularis in experimental fracture repair : a histopathological study Indian J Med Res. 1976 Sep;64(9):1365-8

2) Chopra SS, Patel MR, Gupta LP, Datta IC. Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood Indian J Med Res. 1975 Jun;63(6):824-8.

3) PRASAD GC, UDUPA KN. EFFECT OF CISSUS QUADRANGULARIS ON THE HEALING OF CORTISONE TREATED FRACTURES. Indian J Med Res. 1963 Jul;51:667-76.

4) Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. J Ethnopharmacol. 2003 Dec;89(2-3):245-50.

5) Combaret L, Taillandier D, Dardevet D, Bechet D, Ralliere C, Claustre A, Grizard J, Attaix D Glucocorticoids regulate mRNA levels for subunits of the 19 S regulatory complex of the 26 S proteasome in fast-twitch skeletal muscles. Biochem J. 2004 Feb 15;378(Pt 1):239-46.

6) Chidambara Murthy KN, Vanitha A, Mahadeva Swamy M, Ravishankar GA. Antioxidant and antimicrobial activity of Cissus quadrangularis L. J Med Food. 2003 Summer;6(2):99-105.

7) Panda, J Res Ayurv Siddha, 1990, 11, 7rences

So far I can say this:
- Research is evident that it speeds fracture healing
- Studies have revealed anti-microbial, gastric protection, pro-oxidant activity
- Rave reviews of its use in bodybuilders: Perhaps warrants a legitimate study

I really rate Cissus but haven't really seen any real world proof apart from my own experience. That second post almost sounds like an advert Canuck...

Canuck

As you may know, I suffer with poor shoulders due to various sporting injuries and I am currently dosing with 50% Cissus caps 6 x 400mg per day and my joints have never felt better.

I cannot recommend this high;y enough.

Alriteey then,
I might just take the dive and try some, will post results.
Cheers all

Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.

Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T, Reutrakul V.

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. apanthon@mail.med.cmu.ac.th

Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.

Anyone got nobby stiles to try this out?

cleaver wrote:

Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.

Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T, Reutrakul V.

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. apanthon@mail.med.cmu.ac.th

Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.

Anyone got nobby stiles to try this out?

farmer's do seem a bit better as well!

I also rate it highly - it was the only stuff that sorted my tendon problems out, although I'd definitely buy a better quality product than MP's next time...

I second what Ollie says,good results but dont get MP's stuff.

I dun see it on BSD's list, where shall I get?

On a side Note: My Straps snapped today, and its just made my Wrist worse 1!!

Any place to purchase it from?

http://www.bulkpowders.co.uk
http://www.bulkpowders.co.uk/search.php ... us&x=0&y=0

or http://www.nutraplanet.com/product/nutr ... 400mg.html

Wicked, thanks.

Just a quick'un

Just ordered, what do y'all spect is the descent dose to begin with.

Will post my results with it as well.

Regards

Canuck PT wrote:Just a quick'un

Just ordered, what do y'all spect is the descent dose to begin with.

Will post my results with it as well.

Regards

With the caps 2 to 3 per day would be a good start IMO

I have dabbled with Cissus to try to assist the healing of connective tissue in my forearm, running it at c5g.d-1, and it certainly seems to have helped.

I then bumped into a friend of mine who had put on a substantial amount of muscle since I last saw him. He claimed to be running c15.g-1 split over three doses, and was claiming some 15lb gain in bodyweight. I imagine that the majority of that was lean. Anyhow this inspired me to increase my dosing to 15g.d-1. It is still early days yet, so I will let you guys know how the higher dose goes in a week or so.

If it does increase LBM, I would question the assertions in the article regarding its inhibition of the AA ---> Prostaglandin pathway. I was under the impression that this was required for skeletal muscle gain. My gut feeling is that any anabolic effects are primerally mediated via cortisol inhibition. JMHO.

J

15g a day!! what % ket was that?

11% keto. The same as what I am running currently.
J

hmm uve got me thinking now..wouldnt mind giving this a shot myself.....i can see some logic in it....

kp1512 wrote:hmm uve got me thinking now..wouldnt mind giving this a shot myself.....i can see some logic in it....

Would be a lot less at 50% though.

Alex wrote:

kp1512 wrote:hmm uve got me thinking now..wouldnt mind giving this a shot myself.....i can see some logic in it....

Would be a lot less at 50% though.

8 caps?

Would it not be a lot more than 8 caps?

If each is 400mg at 50% then 2 caps would be 400mg of the herb. Or am I getting the wrong end of the stick?